Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyrimidin-5-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a pyrimidine side chain and an Fmoc-protected α-amino group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides designed for pharmaceutical research and development. It is primarily utilized by medicinal chemists and peptide manufacturers in the biotechnology and pharmaceutical industries to incorporate specific structural motifs that can influence bioactivity and stability.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid monomer for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of peptide-based drug candidates, particularly those targeting protein-protein interactions where the pyrimidine moiety can act as a pharmacophore or hydrogen-bonding element.
• Bioconjugation & Peptide Labeling: The unique pyrimidin-5-yl side chain can be leveraged for further chemical modification or as a handle for bioconjugation strategies.
• Research Biochemicals: Employed in academic and industrial research to study enzyme-substrate interactions, receptor binding, and peptide structure-activity relationships (SAR).
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs producing bespoke peptides for clients in therapeutic and diagnostic applications.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyrimidin-5-Yl)Propanoic Acid
CAS No.	281655-48-9
Molecular Formula	C22H19N3O4
Molecular Weight	389.41 g/mol
Synonyms	Fmoc-3-(5-pyrimidyl)-L-alanine; Fmoc-Pym-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(5-pyrimidinyl)-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(5-pyrimidinyl)propanoic acid; Fmoc-L-3-(5-Pyrimidyl)alanine; Nα-Fmoc-3-(pyrimidin-5-yl)-L-alanine; Fmoc-3-(Pyrimidin-5-yl)-L-Ala-OH; Fmoc-Pym(5)-Ala-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyrimidin-5-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.