Description

3-Methyl-Pyridine-2-Sulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative used as a key building block in organic synthesis. This compound is particularly valued for its role in introducing the sulfonamide functional group, a crucial moiety in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is an essential intermediate for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel sulfonamide-based compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, antibacterial agents, and other biologically active molecules.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide group enhances biological activity and selectivity.
• Chemical Research & Development: Serves as a versatile reagent for introducing sulfonyl groups in medicinal chemistry and process chemistry research programs.
• Material Science: Potential use in the synthesis of functional polymers, ligands for catalysis, and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses producing high-value, complex organic molecules for clients.

Basic Information

Product Name	3-Methyl-Pyridine-2-Sulfonyl Chloride
CAS No.	281221-72-5
Molecular Formula	C6H6ClNO2S
Molecular Weight	191.64 g/mol
Synonyms	2-Methyl-3-pyridinesulfonyl chloride; 3-Picoline-2-sulfonyl chloride; 2-(Chlorosulfonyl)-3-methylpyridine; 3-Methylpyridine-2-sulfonyl chloride; 3-Methyl-2-pyridinesulfonyl chloride; 2-Pyridinesulfonyl chloride, 3-methyl-; 3-Methyl-2-sulfonylchloridopyridine
EINECS	Contact for details

Quality Control

Our 3-Methyl-Pyridine-2-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.