Description

(2-Chloro-5-Methyl-Pyrimidin-4-Yl)-Phenyl-Amine is a high-purity pyrimidine derivative, a crucial building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific substitution pattern enables targeted molecular design. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with specific biological activities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor research and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its pyrimidine core.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalytic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production.

Basic Information

Product Name	(2-Chloro-5-Methyl-Pyrimidin-4-Yl)-Phenyl-Amine
CAS No.	280581-49-9
Molecular Formula	C11H10ClN3
Molecular Weight	219.67 g/mol
Synonyms	4-(Phenylamino)-2-chloro-5-methylpyrimidine; N-Phenyl-2-chloro-5-methylpyrimidin-4-amine; 2-Chloro-5-methyl-N-phenylpyrimidin-4-amine; (2-Chloro-5-methyl-4-pyrimidinyl)phenylamine; 4-Amino-2-chloro-5-methylpyrimidine phenyl derivative; Phenyl-(2-chloro-5-methyl-pyrimidin-4-yl)-amine
EINECS	Contact for details

Quality Control

Our (2-Chloro-5-Methyl-Pyrimidin-4-Yl)-Phenyl-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP-aligned applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.