Description

3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Rel- is a high-purity, advanced pharmaceutical intermediate with a complex, multi-ring structure. This compound is critical for the synthesis of novel quinolone-based antibacterial agents, offering a key building block for targeting resistant bacterial strains. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibiotics and antimicrobial chemotherapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel fluoroquinolone antibiotics.
• Antimicrobial Research: Used in R&D for developing new antibacterial agents with activity against drug-resistant pathogens.
• Chemical Synthesis: Acts as a specialized building block for constructing complex heterocyclic compounds in medicinal chemistry.
• Process Development: Employed in scaling up and optimizing manufacturing routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions in pharmaceutical production.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Rel-
CAS No.	273401-03-9
Molecular Formula	C₂₁H₂₀ClF₂N₃O₃
Molecular Weight	435.85 g/mol
Synonyms	Rel-(1R,2S)-1-(2-Fluorocyclopropyl)-8-chloro-6-fluoro-7-((7S)-7-amino-5-azaspiro[2.4]heptan-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; (1R,2S)-1-(2-Fluorocyclopropyl)-8-chloro-6-fluoro-7-((7S)-7-amino-5-azaspiro[2.4]heptan-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid (rel); 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; WCK 771 Intermediate; Nemonoxacin Intermediate; Antibacterial Quinolone Intermediate; Advanced Fluoroquinolone Building Block
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Our quality assurance includes rigorous testing via HPLC, NMR, and MS for identity, purity, and impurity profile confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.