Description

(S)-Fmoc-2,6-Difluorotyrosine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing fluorinated aromatic side chains into peptide sequences, which can significantly enhance metabolic stability, binding affinity, and membrane permeability. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the incorporation of difluorotyrosine residues.
• Pharmaceutical Research: Synthesis of fluorinated peptide analogs for drug discovery programs targeting GPCRs, enzymes, and protein-protein interactions.
• Proteomics & Chemical Biology: Used to create site-specifically labeled peptides for studying protein structure, function, and dynamics via 19F NMR.
• PET (Positron Emission Tomography) Tracer Development: Serves as a precursor for radiolabeled peptides used in molecular imaging.
• Bioconjugation: Facilitates the controlled modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or biomaterials.
• Agrochemical Research: Building block for developing novel bioactive peptides with improved stability for crop protection.

Basic Information

Item	Detail
Product Name	(S)-Fmoc-2,6-Difluorotyrosine
CAS No.	273221-87-7
Molecular Formula	C24H19F2NO5
Molecular Weight	439.41 g/mol
Synonyms	Fmoc-2,6-Difluoro-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-difluoro-L-tyrosine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(2,6-difluoro-4-hydroxyphenyl)propanoic acid; Fmoc-Difluorotyrosine-OH; Fmoc-2,6-F2-Tyr-OH; Fmoc-L-2,6-Difluorotyrosine; Nα-Fmoc-2,6-difluorotyrosine
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-2,6-Difluorotyrosine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high chemical and chiral purity, which is paramount for reproducible peptide synthesis outcomes. Certificates of Analysis (COA) providing detailed HPLC, NMR, and optical rotation data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.