Description

4H-1,3-Dioxino[5,4-D]Pyrimidin-8-Ol, 6-Amino-4A,7,8,8A-Tetrahydro-7-Hydroxy-2,2-Dimethyl-, (4Ar,8R,8As)- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused-ring heterocyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within antiviral and anticancer research domains.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates.
• Antiviral Drug Research: Used in the research and development of novel nucleoside/nucleotide analog therapeutics.
• Oncology Research: Acts as a building block for potential kinase inhibitors and other targeted cancer therapies.
• Chemical Biology: Employed in the synthesis of molecular probes for studying enzyme mechanisms and cellular pathways.
• Process Chemistry Development: Utilized for route scouting and optimization in pilot-scale API manufacturing.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	4H-1,3-Dioxino[5,4-D]Pyrimidin-8-Ol, 6-Amino-4A,7,8,8A-Tetrahydro-7-Hydroxy-2,2-Dimethyl-, (4Ar,8R,8As)- (9Ci)
CAS No.	272106-61-3
Molecular Formula	C9H13N3O4
Molecular Weight	227.22 g/mol
Synonyms	(4aR,8R,8aS)-6-Amino-4a,7,8,8a-tetrahydro-7-hydroxy-2,2-dimethyl-4H-1,3-dioxino[5,4-d]pyrimidin-8-ol; 6-Amino-4a,7,8,8a-tetrahydro-7-hydroxy-2,2-dimethyl-4H-1,3-dioxino[5,4-d]pyrimidin-8-ol (4aR,8R,8aS)-; 4H-1,3-Dioxino[5,4-d]pyrimidin-8-ol, 6-amino-4a,7,8,8a-tetrahydro-7-hydroxy-2,2-dimethyl-, (4aR,8R,8aS)-; 272106-61-3; A fused-ring pyrimidine derivative; Chiral dioxinopyrimidinol intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and LC-MS for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure full traceability and compliance with research and cGMP-grade material expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container should be kept in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.