Description

Z-(4-tert-Butyloxycarbonyl)-L-Phenylalanine is a protected amino acid derivative, specifically an N-Boc-L-phenylalanine analog, where the tert-butyloxycarbonyl (Boc) group serves as a critical amine-protecting moiety. This compound is essential for facilitating complex multi-step organic syntheses, particularly in peptide chemistry, by preventing unwanted side reactions at the amino group. It is a vital building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Peptide Synthesis: A fundamental building block in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of phenylalanine residues.
• Pharmaceutical Intermediates: Serves as a key chiral intermediate in the research and production of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation: Used in the preparation of peptide-protein conjugates, peptide-drug conjugates, and other bioconjugates for targeted drug delivery and diagnostics.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Biochemical Research: Utilized as a substrate or precursor in enzymatic studies and metabolic pathway research.
• Material Science: Acts as a monomer or modifying agent for creating bio-inspired polymers and functional materials.

Basic Information

Product Name	Z-(4-tert-Butyloxycarbonyl)-L-Phenylalanine
CAS No.	270567-85-6
Molecular Formula	C21H23NO6
Molecular Weight	385.41 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine; N-Cbz-N-Boc-L-phenylalanine; Nα-Cbz-Nε-Boc-L-phenylalanine; (2S)-2-[(Benzyloxy)carbonyl][(2-methylpropan-2-yl)oxycarbonyl]amino]-3-phenylpropanoic acid; Z-N-Boc-L-Phe-OH; Boc-Phe(Z)-OH; N-Carbobenzoxy-N-tert-butoxycarbonyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Z-(4-tert-Butyloxycarbonyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in methanol)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.