Description

Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a thienyl side chain and an Fmoc-protected amine group. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutic agents targeting GPCRs and other protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the automated synthesis of custom peptides with thienyl-containing side chains.
• Pharmaceutical Research & Development: For constructing peptide-based drug candidates, libraries for high-throughput screening, and bioactive peptide analogs.
• Peptidomimetic Design: Serves as a scaffold to create metabolically stable mimics of natural peptides, enhancing drug-like properties.
• Bioconjugation: Used in the preparation of peptide conjugates for diagnostic probes or targeted drug delivery systems.
• Chemical Biology Probes: Incorporation into peptides to study protein function, enzyme-substrate interactions, and cellular signaling pathways.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced biomaterials with specific surface properties.

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid
CAS No.	270262-98-1
Molecular Formula	C23H21NO4S
Molecular Weight	407.48 g/mol
Synonyms	Fmoc-β3-hThienylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2-thienyl)butanoic acid; Fmoc-3-Amino-4-(2-thienyl)butyric acid; Fmoc-Thienyl-β3-homoalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(thiophen-2-yl)butanoic acid; Fmoc-β3-2-Thienyl-Ala-OH; Fmoc-(S)-3-Amino-4-(thiophen-2-yl)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are available upon request, supporting compliance with internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.