Description

Fmoc-(S)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the development of novel peptide-based therapeutics and diagnostic agents, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for creating constrained peptides and peptidomimetics with enhanced stability and biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex peptide sequences.
• Peptidomimetic Drug Discovery: Serves as a crucial scaffold for designing and synthesizing peptide mimics that modulate protein-protein interactions.
• Constrained Peptide Libraries: Used to introduce structural constraints and novel side-chain functionalities into combinatorial peptide libraries for screening.
• API Intermediate Synthesis: An important intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides with fluorophores or other reporter molecules for diagnostic applications.
• Academic and Industrial Research: Employed in biochemical studies to investigate enzyme mechanisms, receptor binding, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid
CAS No.	270065-90-2
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-4-Cyano-L-phenylalanine derivative; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-cyanophenyl)butanoic acid; Fmoc-(S)-Amino(4-cyanophenyl)butyric Acid; N-α-Fmoc-3-Amino-4-(4-cyanophenyl)butanoic acid; Fmoc-L-3-Amino-4-(4-cyanophenyl)butyric acid; Fmoc-3-Amino-4-(4-cyanophenyl)-L-butyric acid; Fmoc-(S)-3-Amino-4-(4-CN-Ph)-But-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.