Description

Fmoc-(S)-3-Amino-4-(Pentafluoro-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for introducing the unique pentafluorophenyl side chain, which can significantly alter the physicochemical and biological properties of target peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: For creating peptide analogs with enhanced metabolic stability, binding affinity, and membrane permeability.
• Fluorinated Peptide Libraries: Enabling the generation of screening libraries to explore structure-activity relationships (SAR) influenced by highly fluorinated aromatic groups.
• Positron Emission Tomography (PET) Tracer Development: Serving as a precursor for labeling peptides with fluorine-18 for diagnostic imaging.
• Chemical Biology Probes: Incorporation into peptides used to study protein-protein interactions and enzyme mechanisms.
• Material Science: For synthesizing specialized fluorinated peptide polymers and surface coatings.

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(Pentafluoro-Phenyl)-Butyric Acid
CAS No.	270063-43-9
Molecular Formula	C26H20F5NO4
Molecular Weight	505.44 g/mol
Synonyms	Fmoc-3-Amino-4-(pentafluorophenyl)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(pentafluorophenyl)butyric acid; Fmoc-Apf-OH; Fmoc-(S)-3-Amino-4-(C6F5)-butyric Acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(pentafluorophenyl)butanoic acid; Fmoc-4-(Pentafluorophenyl)-β-homoalanine; Fmoc-Pentafluorophenyl-homoalanine
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(Pentafluoro-Phenyl)-Butyric Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with relevant standards for pharmaceutical research (cGMP, ICH Q7).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.