Description

Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical chiral building block for constructing complex peptide chains with specific structural and functional properties. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptides on resin, particularly for introducing the unique (S)-3-Amino-4-(2-thienyl)butyric acid side chain.
• Peptidomimetic Drug Discovery: Serves as a key scaffold in medicinal chemistry for creating peptide analogs with enhanced metabolic stability, bioavailability, and target affinity.
• Research & Development of Biologically Active Peptides: Used in academic and industrial R&D to synthesize custom peptides for biological screening, structure-activity relationship (SAR) studies, and probe development.
• Synthesis of Conformationally Constrained Peptides: The thienyl side chain can be employed to introduce conformational constraints or novel interactions within a peptide sequence.
• Production of Reference Standards and APIs: Suitable for the synthesis of high-purity reference compounds and as an intermediate in the manufacturing of Active Pharmaceutical Ingredients (APIs) for peptide-based therapeutics.

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid
CAS No.	269726-90-1
Molecular Formula	C23H21NO4S
Molecular Weight	407.48 g/mol
Synonyms	Fmoc-(S)-3-Amino-4-(2-thienyl)butanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2-thienyl)butyric Acid; Fmoc-Atb-OH; Fmoc-3-Amino-4-(2-thienyl)butyric Acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(thiophen-2-yl)butanoic Acid; N-α-Fmoc-3-amino-4-(2-thienyl)butyric acid; Fmoc-β-homoTyr(2-Thienyl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(2-Thienyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.