Description

Fmoc-(R)-3-Amino-4-(2-Naphthyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a bulky, hydrophobic 2-naphthyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where its structure is engineered to facilitate the construction of complex peptides with enhanced stability and specific biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the sequential assembly of custom peptide sequences.
• Pharmaceutical Research & Development: Used to incorporate a rigid, aromatic moiety into peptide backbones to modulate bioavailability, receptor binding affinity, and metabolic stability.
• Peptidomimetic Design: Serves as a scaffold for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Bioconjugation and Probe Development: The reactive amino and carboxyl groups allow for site-specific labeling and conjugation to other molecules or surfaces.
• Academic Research: Employed in studies exploring protein-protein interactions, enzyme inhibitors, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(2-Naphthyl)-Butyric Acid
CAS No.	269398-91-6
Molecular Formula	C29H25NO4
Molecular Weight	451.52 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(2-naphthyl)butanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2-naphthyl)butyric Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(naphthalen-2-yl)butanoic Acid; Fmoc-D-2-Nal(3)-OH; Fmoc-3-Amino-4-(2-naphthyl)butyric Acid; Fmoc-β-homo-2-naphthylalanine; Nα-Fmoc-3-amino-4-(2-naphthyl)butyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(2-Naphthyl)-Butyric Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, essential for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.