Description

Fmoc-(R)-3-Amino-4-(4-Nitro-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This chiral building block is critical for introducing specific structural motifs and functionalities into peptide chains, enabling the development of novel bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: For constructing peptide libraries and modifying peptide backbones to enhance stability, bioavailability, or receptor binding affinity.
• Bioconjugation: Serving as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter groups.
• Proteomics Research: Used in the synthesis of substrate analogs, enzyme inhibitors, or activity-based probes for studying protease function.
• Chemical Biology: Incorporation into engineered peptides to study protein-protein interactions and cellular signaling pathways.
• API Intermediate: Potential use as a chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) with specific stereochemical requirements.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(4-Nitro-Phenyl)-Butyric Acid
CAS No.	269398-78-9
Molecular Formula	C25H22N2O6
Molecular Weight	446.46 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(4-nitrophenyl)butanoic acid; Fmoc-D-3-Amino-4-(4-nitrophenyl)butyric acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid; Fmoc-(R)-Amino(4-nitrophenyl)butyric Acid; Fmoc-3-Amino-4-(4-NO2-Ph)-But-OH; Fmoc-D-4-Nitro-Phe(3-NH2)-OH; Fmoc-(R)-3-Amino-4-(p-nitrophenyl)butyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(4-Nitro-Phenyl)-Butyric Acid is manufactured under strict quality systems to ensure high chemical and chiral purity, which is essential for reproducible peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers should be sealed under inert atmosphere when possible and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.