Description

(R)-Fmoc-4-Amino-6-Methyl-Heptanoic Acid CAS NO 269078-75-3 is a high-purity, non-natural amino acid derivative featuring a chiral center and an Fmoc-protected amine group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise introduction of a branched, hydrophobic side chain. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require enantiomerically pure intermediates for creating novel therapeutic candidates and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides with specific structural features.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporates a bulky, hydrophobic side chain to mimic protein-protein interactions and improve metabolic stability of drug candidates.
• Bioconjugation and Probe Synthesis: Serves as a versatile intermediate for creating labeled peptides or peptide-drug conjugates for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of compounds for high-throughput screening in drug discovery.
• Academic & Institutional Research: A valuable reagent for studying protein folding, structure-activity relationships (SAR), and biochemical pathways.

Basic Information

Product Name	(R)-Fmoc-4-Amino-6-Methyl-Heptanoic Acid
CAS No.	269078-75-3
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-(R)-4-Amino-6-methylheptanoic acid; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-6-methylheptanoic acid; (R)-Fmoc-Ahmp-OH; 4-Amino-6-methylheptanoic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, (R)-; Fmoc-D-4-Amino-6-methylheptanoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-6-methylheptanoic acid; (R)-Fmoc-4-Amino-6-Methyl-Heptanoic Acid CAS NO 269078-75-3
EINECS	Contact for details

Quality Control

Our (R)-Fmoc-4-Amino-6-Methyl-Heptanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification methods, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.