Description

(R)-4-(Fmoc-Amino)-5-Phenylpentanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and an Fmoc-protected amine group. This compound is a critical chiral building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of specific stereochemistry and side-chain functionality. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, protease inhibitors, and other bioactive molecules where precise spatial orientation is required for activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in Fmoc-strategy solid-phase peptide synthesis (SPPS) to incorporate a specific (R)-configured amino acid residue into peptide chains.
• Peptidomimetic Design: Serves as a building block for creating peptidomimetics, which are molecules that mimic the structure and function of natural peptides but with enhanced stability and bioavailability.
• Protease Inhibitor Development: Employed in the synthesis of potential inhibitors for enzymes like renin, HIV protease, and other aspartic proteases.
• Chemical Biology Research: Utilized as a tool compound for studying protein-protein interactions, enzyme mechanisms, and signal transduction pathways.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new lead compounds with biological activity.

Basic Information

Product Name	(R)-4-(Fmoc-Amino)-5-Phenylpentanoic Acid
CAS No.	269078-74-2
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	(R)-4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-phenylpentanoic acid; Fmoc-D-homoPhe(4)-OH; Fmoc-(R)-4-Amino-5-phenylpentanoic acid; (R)-4-(Fmoc-Amino)-5-phenylvaleric acid; (4R)-4-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-5-phenylpentanoic acid; (R)-4-Fmoc-amino-5-phenylpentanoic acid; Fmoc-D-4-Amino-5-phenylpentanoic acid
EINECS	Contact for details

Quality Control

Our (R)-4-(Fmoc-Amino)-5-Phenylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), chiral excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.