Description

Fmoc-Orn(Dde)-Oh CAS NO 269062-80-8 is a protected amino acid derivative, specifically an Fmoc- and Dde-protected ornithine, designed for solid-phase peptide synthesis (SPPS). This compound is critical for enabling the sequential and selective assembly of complex peptides, particularly those requiring orthogonal protection strategies for side-chain functionalities. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, where precise control over peptide structure is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled, stepwise construction of peptide chains on resin supports.
• Orthogonal Protection Strategy: Enables selective deprotection of the Dde group (using hydrazine) while keeping the Fmoc group intact, allowing for the introduction of specific modifications at the ornithine side chain.
• Synthesis of Branched or Cyclic Peptides: The ornithine side chain provides an attachment point for creating complex peptide architectures, including dendrimers and constrained cyclic structures.
• Bioconjugation and Labeling: Used to incorporate reactive handles (via the deprotected amine) for attaching fluorophores, biotin, or other probes to peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and development of peptide-based therapeutics, including antimicrobial peptides and hormone analogs.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.

Basic Information

Item	Detail
Product Name	Fmoc-Orn(Dde)-Oh
CAS No.	269062-80-8
Molecular Formula	C31H31N3O6
Molecular Weight	541.60 g/mol
Synonyms	Fmoc-Orn(Dde)-OH; Nα-Fmoc-Nδ-Dde-L-ornithine; Fmoc-L-Orn(Dde)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)pentanoic acid; Nα-(9-Fluorenylmethyloxycarbonyl)-Nδ-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)-L-ornithine; Fmoc-Orn(Dde)-OH (SPPS grade); Fmoc-Ornithine(Dde)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Orn(Dde)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.