Description

Fmoc-D-Lys(Dnp)-Oh CAS NO 269061-41-8 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, optically active building blocks with orthogonal protecting groups. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating D-configured lysine with selectively removable side-chain protection (Dnp) into complex peptide sequences.
• Antimicrobial Peptide (AMP) Research: For the development of novel peptides with modified structures to enhance stability, activity, or reduce susceptibility to enzymatic degradation.
• Peptidomimetic Drug Discovery: Enables the creation of peptide-like molecules with improved pharmacological properties for targeting specific diseases.
• Bioconjugation and Labeling: Serves as a precursor for creating peptide conjugates with fluorescent probes, drugs, or other functional molecules via its free carboxylic acid and protected amine groups.
• Structure-Activity Relationship (SAR) Studies: Used to systematically modify peptide structures to understand the impact of specific D-amino acid substitutions on biological function.
• GPCR Ligand and Hormone Analog Development: For the synthesis of analogs of natural peptide hormones and neurotransmitters to study receptor interactions.

Basic Information

Product Name	Fmoc-D-Lys(Dnp)-Oh
CAS No.	269061-41-8
Molecular Formula	C27H26N4O8
Molecular Weight	534.52 g/mol
Synonyms	Fmoc-D-lysine(Dnp)-OH; Nα-Fmoc-Nε-Dnp-D-lysine; Fmoc-D-Lys(Dnp)-OH; N-(9-Fluorenylmethoxycarbonyl)-N'-2,4-dinitrophenyl-D-lysine; D-Fmoc-Lys(Dnp)-OH; Fmoc-D-Lysine(Dnp)-OH; Nα-(9-Fluorenylmethyloxycarbonyl)-Nε-(2,4-dinitrophenyl)-D-lysine; (2R)-6-[(2,4-Dinitrophenyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Lys(Dnp)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm optical integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.