Description

Fmoc-4-[(Methylsulfonyl)Amino]-Dl-Phenylalanine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for introducing a sulfonamide-modified phenylalanine residue into peptide chains, enabling the study of protein-protein interactions and the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of complex peptides containing sulfonamido-phenylalanine analogs.
• Medicinal Chemistry & Drug Discovery: Used to create peptide libraries for screening against biological targets, particularly in oncology and metabolic disease research.
• Proteomics Research: Employed in the synthesis of substrate peptides for kinase and protease activity assays.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Tool Development: Integral for synthesizing peptide probes to investigate enzyme mechanisms and signaling pathways.
• Academic Research: Used in university laboratories for graduate-level research in organic synthesis and peptide science.

Basic Information

Product Name	Fmoc-4-[(Methylsulfonyl)Amino]-Dl-Phenylalanine
CAS No.	266999-20-6
Molecular Formula	C26H26N2O6S
Molecular Weight	494.56 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(methylsulfonyl)amino]-DL-phenylalanine; Fmoc-DL-Phe(4-NHMs)-OH; Fmoc-4-(Methylsulfonylamino)phenylalanine; N-Fmoc-4-(N-methylsulfonamido)phenylalanine; (±)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(methylsulfonyl)amino]phenylalanine; Fmoc-Phe(4-NHSO2Me)-OH; Fmoc-4-(N-Mesylamino)phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-4-[(Methylsulfonyl)Amino]-Dl-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.