Description

2,4-Difluoro-D-Phenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a critical chiral building block in the synthesis of novel peptide-based therapeutics and diagnostic agents, where the introduction of fluorine atoms can dramatically alter metabolic stability, bioavailability, and binding affinity. It is primarily needed by research institutions, pharmaceutical companies, and CROs/CMOs engaged in the development of fluorinated peptides, protease inhibitors, and targeted radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide drugs and bioactive molecules.
• Protease Inhibitor Development: Used in research for creating potent inhibitors targeting specific enzymes.
• PET (Positron Emission Tomography) Tracer Precursor: Serves as a building block for fluorine-18 labeled radiopharmaceuticals for diagnostic imaging.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the effects of fluorination on peptide properties.
• Bioconjugation & Probe Synthesis: Utilized for creating fluorescent or affinity-labeled peptide probes for biochemical assays.
• Asymmetric Synthesis: Acts as a valuable starting material or intermediate in sophisticated chiral synthesis routes.

Basic Information

Product Name	2,4-Difluoro-D-Phenylalanine
CAS No.	266360-60-5
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	D-2,4-Difluorophenylalanine; (R)-2-Amino-3-(2,4-difluorophenyl)propanoic acid; (R)-2,4-Difluorophenylalanine; 2,4-Difluoro-D-phenylalanine; 2,4-DFPA; D-2,4-Difluoro-Phe; (2R)-2-Amino-3-(2,4-difluorophenyl)propanoic acid; F2Phe(2,4)-OH
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-D-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality commitment supports compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.