Description

Methyl trans-4-(4-Chloro-[1]benzothieno[2,3-d]-pyrimidin-2-yl)-cyclohexanecarboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key building block for creating targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing innovative drug candidates, particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel benzothienopyrimidine-based drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Oncology Drug Development: Serves as a core scaffold for the synthesis of potential kinase inhibitors and other anticancer agents.
• Antiviral Agent Synthesis: Employed in the research and development of compounds targeting viral replication mechanisms.
• Fine Chemical Synthesis: Utilized in custom synthesis and scale-up processes for high-value, complex organic molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production campaigns.

Basic Information

Item	Details
Product Name	Methyl trans-4-(4-Chloro-[1]benzothieno[2,3-d]-pyrimidin-2-yl)-cyclohexanecarboxylate
CAS No.	266321-48-6
Molecular Formula	C18H15ClN2O2S
Molecular Weight	358.84 g/mol
Synonyms	trans-Methyl 4-(4-chloro[1]benzothieno[2,3-d]pyrimidin-2-yl)cyclohexanecarboxylate; Methyl 4-[(4-chloro[1]benzothieno[2,3-d]pyrimidin-2-yl)]cyclohexanecarboxylate; 4-Chloro-2-(trans-4-methoxycarbonylcyclohexyl)[1]benzothieno[2,3-d]pyrimidine; 266321-48-6; Benzothieno[2,3-d]pyrimidine derivative
EINECS	Contact for details

Quality Control

Our Methyl trans-4-(4-Chloro-[1]benzothieno[2,3-d]-pyrimidin-2-yl)-cyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We support development from research to commercial scale with specifications that can meet GMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.