Description

(Tetrahydro-Pyran-4-Yl)-Methanesulfonyl Chloride CAS NO 264608-29-9 is a versatile and reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to introduce the (tetrahydro-pyran-4-yl)methanesulfonyl moiety, a valuable functional group for modulating the physicochemical properties of target molecules. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the sulfonyl group can enhance biological activity and selectivity.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling, cross-linking, or modifying biomolecules in probe and tool compound development.
• Material Science Precursor: Employed in the synthesis of functional polymers and advanced materials requiring specific sulfonamide or sulfonate functionalities.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Research & Development: Fundamental reagent in academic and industrial R&D labs for exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	(Tetrahydro-Pyran-4-Yl)-Methanesulfonyl Chloride
CAS No.	264608-29-9
Molecular Formula	C7H13ClO3S
Molecular Weight	212.69 g/mol
Synonyms	4-(Chlorosulfonylmethyl)tetrahydropyran; (Oxan-4-yl)methanesulfonyl chloride; (THP-4-yl)methanesulfonyl chloride; Tetrahydro-2H-pyran-4-ylmethanesulfonyl chloride; (Tetrahydropyran-4-yl)methanesulfonyl chloride; 4-(Methanesulfonyl chloride)tetrahydropyran; (4-Tetrahydropyranyl)methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our (Tetrahydro-Pyran-4-Yl)-Methanesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.