Description

Dabcyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-Edans CAS NO 263718-22-5 is a synthetic, fluorogenic peptide substrate designed for protease activity assays. This compound is critical for biochemical research and pharmaceutical development, enabling the sensitive and continuous monitoring of enzymatic cleavage. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies involved in protease inhibitor screening and enzyme kinetics studies.

Application

• Protease Activity Assays: As a fluorogenic substrate for continuous, real-time monitoring of protease enzymatic activity.
• Drug Discovery Screening: High-throughput screening (HTS) of potential protease inhibitors for therapeutic development.
• Enzyme Kinetics Studies: Determination of kinetic parameters (Km, Vmax, kcat) for specific proteases.
• Diagnostic Development: A key component in the development of in-vitro diagnostic tests for diseases involving protease dysregulation.
• Biochemical Research: Used in academic and industrial labs to study protease function, specificity, and mechanism of action.
• Quality Control in Biologics: Monitoring protease activity during the production and purification of biopharmaceuticals.

Basic Information

Product Name	Dabcyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-Edans
CAS No.	263718-22-5
Molecular Formula	C78H108N18O20S
Molecular Weight	1633.9 g/mol
Synonyms	Dabcyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-Edans; Fluorogenic Protease Substrate; Dabcyl-E-R-Nle-F-L-S-F-P-Edans; EDANS/Dabcyl FRET Peptide; 5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid (Edans) / 4-((4-(Dimethylamino)phenyl)azo)benzoic acid (Dabcyl) labeled peptide; Thrombin Fluorogenic Substrate; FRET-based Peptide Substrate; CAS 263718-22-5
EINECS	Contact for details

Quality Control

Our Dabcyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-Edans is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.