Description

n-Me-Glu-Oh·Hcl CAS NO 261943-12-8 is a protected amino acid derivative, specifically the hydrochloride salt of N-methyl-L-glutamic acid. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for the development of peptides, active pharmaceutical ingredients (APIs), and complex molecular entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the N-methyl glutamic acid moiety, which can enhance metabolic stability and alter conformational properties.
• Bioconjugation & Probe Development: Acts as a modified amino acid for creating labeled peptides or protein conjugates used in biochemical research and diagnostic assays.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new drug candidates, particularly in oncology and neurology.
• Fine Chemical Synthesis: A valuable intermediate for constructing complex natural products and specialty chemicals requiring specific stereochemistry.
• Academic & Industrial R&D: Serves as a high-purity reference standard and building block in chemical research and development laboratories worldwide.

Basic Information

Item	Detail
Product Name	n-Me-Glu-Oh·Hcl
CAS No.	261943-12-8
Molecular Formula	C₆H₁₁NO₄·HCl
Molecular Weight	197.62 g/mol (Free base: 161.16 g/mol)
Synonyms	N-Methyl-L-glutamic acid hydrochloride; (S)-2-(Methylamino)pentanedioic acid hydrochloride; H-N-Me-Glu-OH·HCl; N-Methylglutamic acid HCl; L-N-Methylglutamic acid hydrochloride; N-Methylglutamate hydrochloride; Protected glutamic acid derivative
EINECS	Contact for details

Quality Control

Our n-Me-Glu-Oh·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for water content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.