Description

2,3-Difluoro-4-Methylbenzyl Bromide is a versatile and high-value organobromide building block characterized by its reactive benzyl bromide group and strategically placed fluorine substituents. This compound is essential for introducing the difluoromethylbenzyl moiety into complex molecular architectures, enabling fine-tuning of electronic and steric properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Cross-Coupling Reactions: The benzyl bromide functionality makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Functionalized Ligand Preparation: Employed in the synthesis of specialized ligands for catalysis and material science applications.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process R&D for exploring new chemical entities and optimizing synthetic routes.

Basic Information

Product Name	2,3-Difluoro-4-Methylbenzyl Bromide
CAS No.	261763-43-3
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	1-(Bromomethyl)-2,3-difluoro-4-methylbenzene; (2,3-Difluoro-4-methylphenyl)methyl bromide; α-Bromo-2,3-difluoro-4-methyltoluene; 2,3-Difluoro-4-methylbenzylbromide; 4-Methyl-2,3-difluorobenzyl bromide; 2,3-Difluoro-p-tolylmethyl bromide
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-Methylbenzyl Bromide is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.