Description

2,3-Difluoro-4-Methoxyphenol is a fluorinated phenolic compound that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine atoms and a methoxy group on the phenol ring, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its fluorine atoms can enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoromethoxyphenol moiety can contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to influence polarity and mesomorphic properties.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with enhanced chemical resistance, thermal stability, or specific surface properties.
• Organic Electronic Materials: Investigated as a building block for electron-transport materials, semiconductors, and other components in OLEDs and organic photovoltaics.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new reaction pathways involving fluorinated aromatics.

Basic Information

Product Name	2,3-Difluoro-4-Methoxyphenol
CAS No.	261763-29-5
Molecular Formula	C7H6F2O2
Molecular Weight	160.12 g/mol
Synonyms	4-Methoxy-2,3-difluorophenol; 2,3-Difluoro-4-methoxy-1-hydroxybenzene; 2,3-Difluoro-4-methoxyphenol; 1-Hydroxy-4-methoxy-2,3-difluorobenzene; Phenol, 2,3-difluoro-4-methoxy-; 2,3-Difluoro-4-methoxyphenol (CAS 261763-29-5)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Methoxyphenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and physical characteristics. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.