Description

5-Chloro-2-(Trifluoromethyl)Benzyl Alcohol is a versatile fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and enhance the metabolic stability of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and etherifications to create complex aromatic and heterocyclic structures for research purposes.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Benzyl Alcohol
CAS No.	261763-21-7
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	(5-Chloro-2-(trifluoromethyl)phenyl)methanol; α-(Trifluoromethyl)-5-chloro-o-tolyl alcohol; 2-Trifluoromethyl-5-chlorobenzyl alcohol; 1-(Chloro-5)-(trifluoromethyl-2) benzyl alcohol; 5-Chloro-α,α,α-trifluoro-o-tolyl alcohol; 5-Chloro-2-trifluoromethylbenzenemethanol; Benzenemethanol, 5-chloro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.