Description

3-Chloro-2,6-Difluorophenol is a halogenated phenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorophenol core structure.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a monomer or modifier in the production of specialty polymers, such as polyarylates and high-performance resins, to impart specific chemical resistance or thermal properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the phenol moiety into complex molecular architectures.
• Research & Development: Essential compound for medicinal chemistry programs and material science research exploring new chemical entities and functional groups.

Basic Information

Product Name	3-Chloro-2,6-Difluorophenol
CAS No.	261762-51-0
Molecular Formula	C6H3ClF2O
Molecular Weight	164.54 g/mol
Synonyms	2,6-Difluoro-3-chlorophenol; 3-Chloro-2,6-difluorophenol; Phenol, 3-chloro-2,6-difluoro-; 3-Chloro-2,6-difluoro-1-hydroxybenzene; 1-Chloro-2,6-difluoro-3-hydroxybenzene
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2,6-Difluorophenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and we support custom purity specifications for cGMP or other regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as oxidizing agents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.