Description

Boc-3-Methoxy-L-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound matters because it provides a crucial building block for constructing complex peptides and peptidomimetics with enhanced stability and specific bioactivity. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators. Its protected amine group allows for selective deprotection in multi-step synthetic sequences.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of methoxy-substituted phenylalanine into peptide chains.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting metabolic and neurological disorders.
• Peptidomimetic Drug Design: Used to create stable, non-hydrolyzable peptide analogs for drug discovery programs.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of probes, tags, or drug molecules to peptides and proteins.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms through the synthesis of tailored peptide substrates.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Boc-3-Methoxy-L-Phenylalanine
CAS No.	261360-71-8
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3-methoxy-L-phenylalanine; Boc-3-MeO-L-Phe-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-methoxyphenyl)propanoic acid; tert-Butyl (S)-(1-(3-methoxyphenyl)-2-carboxyethyl)carbamate; 3-Methoxy-L-phenylalanine, N-Boc-; Boc-L-3-Methoxyphenylalanine; N-Boc-3-methoxy-L-phenylalanine; Boc-3-Methoxy-L-Phe
EINECS	Contact for details

Quality Control

Our Boc-3-Methoxy-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]20/D	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.