Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(Phenylsulfonyl)-1-Piperazinyl]- is a high-purity advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance due to its critical role in the synthesis of novel fluoroquinolone antibiotics. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in the development of next-generation antibacterial agents. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency for reliable process chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Development: Serves as a crucial precursor in the multi-step synthesis of target API molecules.
• Process Chemistry & Scale-Up: Supplied for process development, optimization, and pilot-scale production runs.
• Contract Manufacturing (CMO): Essential raw material for contract manufacturing organizations specializing in potent and complex APIs.
• Reference Standard: High-purity material suitable for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(Phenylsulfonyl)-1-Piperazinyl]-
CAS No.	260560-51-8
Molecular Formula	C23H22FN3O5S
Molecular Weight	471.50 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-phenylsulfonyl-1-piperazinyl)-3-quinolinecarboxylic acid; 7-(4-(Phenylsulfonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(phenylsulfonyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Fluoroquinolone Intermediate; Antibacterial Intermediate; CAS 260560-51-8.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with cGMP and ICH guidelines for pharmaceutical intermediates. Specifications are aligned with the rigorous demands of preclinical and clinical-stage API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers must be kept sealed under inert atmosphere when not in use to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.