Description

Fmoc-Arg(Pbf)-Ol CAS NO 260450-75-7 is a protected amino acid derivative, specifically an Fmoc-protected arginine with Pbf side-chain protection and a free carboxylic acid group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient assembly of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, stepwise synthesis of peptides containing arginine residues.
• Pharmaceutical Research: Used in the discovery and development of peptide therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug delivery systems.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening against biological targets.
• Academic & Contract Research: A fundamental reagent in university and CRO laboratories for studying protein-protein interactions and peptide structure-activity relationships.
• GMP Manufacturing: Suitable for use in the production of Active Pharmaceutical Ingredients (APIs) for clinical and commercial peptide drugs under appropriate quality controls.

Basic Information

Product Name	Fmoc-Arg(Pbf)-Ol
CAS No.	260450-75-7
Molecular Formula	C34H48N4O7S
Molecular Weight	656.84 g/mol
Synonyms	Fmoc-L-arginine(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-Arg(Pbf)-OH; Fmoc-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Nα-(9-Fluorenylmethoxycarbonyl)-Nω-[2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl]-L-arginine; Fmoc-Arg(Pbf)-Ol (common abbreviation); Fmoc-L-Arg(Pbf)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Pbf)-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and GMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.