Description

tert-Butyl 7,8-Dihydro-2-(Methylsulfonyl)Pyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key synthetic building block for the creation of novel kinase inhibitors and other targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for kinase-targeted therapies.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in oncology and other therapeutic areas.
• Chemical Biology Probe Synthesis: Employed to create tool compounds for studying specific biological pathways and target validation.
• Process Development: Serves as a standard or starting material for scaling up and optimizing synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 7,8-Dihydro-2-(Methylsulfonyl)Pyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate
CAS No.	259809-79-5
Molecular Formula	C14H19N3O4S
Molecular Weight	325.38 g/mol
Synonyms	tert-Butyl 2-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate; 6-(tert-Butoxycarbonyl)-2-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 2-Methanesulfonyl-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 259809-79-5; Pyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid, 7,8-dihydro-2-(methylsulfonyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7,8-Dihydro-2-(Methylsulfonyl)Pyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider holding under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.