Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[(3R)-3-Methyl-1-Piperazinyl]-4-Oxo- is a high-purity, structurally complex pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of advanced fluoroquinolone antibiotics, offering critical chiral specificity and functional group integrity for downstream API manufacturing. It is essential for pharmaceutical R&D laboratories and large-scale production facilities focused on developing and producing next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A critical chiral intermediate in the production of advanced fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, optimization, and synthesis of novel antibacterial compounds.
• Process Chemistry & Scale-Up: Serves as a validated starting material for process development and commercial-scale GMP manufacturing.
• Reference Standard: Employed as an analytical standard for quality control and regulatory compliance testing of final drug substances.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[(3R)-3-Methyl-1-Piperazinyl]-4-Oxo-
CAS No.	258879-53-7
Molecular Formula	C19H22FN3O4
Molecular Weight	375.40 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (R)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; Dexlansoprazole Intermediate (related synthon); Fluoroquinolone Intermediate; Chiral Piperazine Quinoline Derivative; 258879-53-7; UNII-Contact for details
EINECS	Contact for details

Quality Control

This pharmaceutical intermediate is manufactured under strict quality management systems. All batches are subjected to rigorous analytical testing, including HPLC for purity and chiral assay, residual solvent analysis (GC), and identification by IR and NMR, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. Production can be aligned with GMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.