Description

Phenol, 3,5-Difluoro-4-(1-Methylethyl)- (9Ci) is a specialized fluorinated phenolic compound that serves as a valuable building block in advanced organic synthesis. Its unique structure, featuring fluorine atoms and an isopropyl group on the phenol ring, makes it a critical intermediate for creating high-performance materials and active pharmaceutical ingredients. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise, high-purity intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorinated phenolic core enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing monomers used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to improve electronic properties and durability.
• Polymer & Resin Modifier: Incorporated into specialty polymers, epoxy resins, and polycarbonates to impart enhanced thermal stability, chemical resistance, and specific optical characteristics.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and for introducing the difluorophenol moiety into complex molecular architectures.
• Research & Development: Critical material for medicinal chemistry and process chemistry research in both academic and industrial settings for exploring new chemical entities.

Basic Information

Product Name	Phenol, 3,5-Difluoro-4-(1-Methylethyl)- (9Ci)
CAS No.	258874-91-8
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	4-Isopropyl-3,5-difluorophenol; 3,5-Difluoro-4-isopropylphenol; 4-(1-Methylethyl)-3,5-difluorophenol; 3,5-Difluoro-4-(propan-2-yl)phenol; 2,6-Difluoro-4-isopropylphenol; Phenol, 4-isopropyl-3,5-difluoro-; Difluoroisopropylphenol
EINECS	Contact for details

Quality Control

Every batch of Phenol, 3,5-Difluoro-4-(1-Methylethyl)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.