Description

Ghrelin (Rat) CAS NO 258338-12-4 is a synthetic peptide hormone, specifically the rat isoform of the endogenous ligand for the growth hormone secretagogue receptor (GHSR). This compound is a critical research tool for studying appetite regulation, energy homeostasis, and growth hormone release mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on metabolic disorders, endocrinology, and neurobiology.

Application

• Neuroscience and Appetite Research: Used to investigate the central and peripheral mechanisms of hunger signaling and food intake regulation in rodent models.
• Endocrinology Studies: Essential for in vitro and in vivo studies on growth hormone (GH) secretion and the GH/IGF-1 axis.
• Metabolic Disorder Research: Applied in preclinical research for conditions like obesity, cachexia, and Prader-Willi syndrome to understand ghrelin's pathophysiological role.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for GHSR agonists and antagonists.
• Behavioral Pharmacology: Utilized to study the effects of ghrelin on motivation, reward, and stress-related behaviors in animal models.
• Biomarker Assay Development: Acts as a calibrator and control in the development of immunoassays (ELISA, RIA) for detecting ghrelin levels.

Basic Information

Product Name	Ghrelin (Rat)
CAS No.	258338-12-4
Molecular Formula	C₁₄₉H₂₄₆N₄₈O₄₂
Molecular Weight	3314.8 g/mol
Synonyms	Rat Ghrelin; Ghrelin (rat); n-Octanoyl-Ghrelin (rat); Des-Gln14-Ghrelin (rat); Growth Hormone Secretagogue; GHS; Lenomorelin; GHRP; Appetite-Regulating Hormone; GHS-R Ligand
EINECS	Contact for details

Quality Control

Our Ghrelin (Rat) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to GMP principles for peptide synthesis, and our quality system is designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Stimulates growth hormone release in rat pituitary cell assays (Data available on request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.