Description

n-Me-Thr(Bzl)-Oh Hcl is a protected amino acid derivative, specifically the hydrochloride salt of N-methyl-O-benzyl-L-threonine. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and side-chain functionality. It is primarily utilized by pharmaceutical researchers, process development chemists, and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules. Its high purity and defined structure are essential for ensuring the reproducibility and efficacy of advanced pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and proteins.
• Peptidomimetic Drug Discovery: Used to incorporate modified threonine residues into novel drug candidates targeting enzymes and receptors.
• Protease Inhibitor Development: Serves as a crucial component in the structure of inhibitors for proteases like thrombin, renin, and HIV protease.
• Bioconjugation & Labeling: The protected benzyl and methyl groups allow for selective deprotection and conjugation in bioconjugation chemistry.
• Academic & Industrial Research: Employed in R&D laboratories for studying protein structure-function relationships and developing new synthetic methodologies.
• Custom Peptide Synthesis: A high-purity starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides for clients.

Basic Information

Item	Detail
Product Name	n-Me-Thr(Bzl)-Oh Hcl
CAS No.	257288-46-3
Molecular Formula	C13H20ClNO3
Molecular Weight	273.75 g/mol
Synonyms	N-Methyl-O-benzyl-L-threonine hydrochloride; (2S,3R)-2-(Methylamino)-3-[(phenylmethoxy)methyl]butanoic acid hydrochloride; L-Threonine, N-methyl-O-benzyl-, hydrochloride; N-Me-Thr(Bzl)-OH•HCl; Fmoc-N-Me-Thr(Bzl)-OH precursor; Protected N-methylthreonine hydrochloride
EINECS	Contact for details

Quality Control

Our n-Me-Thr(Bzl)-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.