Description

H-Arg(Pbf)-Ome Hcl is a protected arginine derivative, specifically the methyl ester hydrochloride salt with a 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) protecting group on the guanidino side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of arginine residues while preventing side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and production of peptide active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Serves as a precursor for introducing arginine residues into modified peptides for targeted drug delivery or imaging probes.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.
• Vaccine Development: Used in the synthesis of antigenic peptide sequences for vaccine research.

Basic Information

Product Name	H-Arg(Pbf)-Ome Hcl
CAS No.	257288-19-0
Molecular Formula	C₂₂H₃₇N₅O₆S • HCl
Molecular Weight	552.09 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; L-Arginine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-[[2,2,4,6,7-pentamethyldihydro-5-benzofuranyl)sulfonyl]-; Fmoc-L-arginine(Pbf)-OH; Fmoc-Arg(Pbf)-OH; Nα-Fmoc-Nω-Pbf-L-arginine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonamido)pentanoic acid; Fmoc-Arg(Pbf)
EINECS	Contact for details

Quality Control

Our H-Arg(Pbf)-Ome Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.