Description

1-(3,4-Difluorophenyl)Piperazine is a high-purity, versatile piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where its difluorophenyl moiety is strategically important. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of central nervous system (CNS) active drugs, including potential antidepressants and antipsychotics.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, where the fluorine atoms can improve biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific electronic or structural properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	1-(3,4-Difluorophenyl)Piperazine
CAS No.	255893-57-3
Molecular Formula	C10H12F2N2
Molecular Weight	198.21 g/mol
Synonyms	1-(3,4-Difluorophenyl)piperazine; 3,4-Difluorophenylpiperazine; 1-(3,4-Difluorophenyl)piperazine hydrochloride (salt form); 3,4-DFPP; Piperazine, 1-(3,4-difluorophenyl)-; 255893-57-3; 1-(3,4-Difluorophenyl)piperazine free base
EINECS	Contact for details

Quality Control

Every batch of 1-(3,4-Difluorophenyl)Piperazine is manufactured and tested under strict quality management systems to ensure consistency and reliability. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation, to meet the stringent requirements of pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.