Description

(Des-Asp187,Met186)-Melanocyte Protein Pmel 17 (185-193) (Human, Bovine, Mouse) CAS NO 255710-51-1 is a synthetic peptide fragment derived from the melanocyte-specific protein Pmel17, a key component in melanosome biogenesis and melanin synthesis. This high-purity research-grade peptide is critical for advancing immunological and biochemical studies related to melanocyte function and pigmentation disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on oncology, dermatology, and autoimmune disease research.

Application

• Biomedical Research: Used as a critical antigen in immunological assays to study melanocyte-specific immune responses.
• Antibody Development & Validation: Serves as a standard and immunogen for the production and characterization of monoclonal and polyclonal antibodies targeting Pmel17.
• Melanoma Research: Essential for investigating the role of Pmel17 epitopes in melanoma progression and as a potential target for immunotherapy.
• Diagnostic Assay Development: Employed in the development of ELISA, Western Blot, and other immunoassays for detecting autoantibodies or studying protein interactions.
• Cell Signaling Studies: Utilized to probe intracellular signaling pathways and protein-protein interactions involving the Pmel17 protein in melanocytes.
• Vaccine Research: Investigated as a peptide component in experimental cancer vaccine formulations targeting melanoma-associated antigens.

Basic Information

Product Name	(Des-Asp187,Met186)-Melanocyte Protein Pmel 17 (185-193) (Human, Bovine, Mouse)
CAS No.	255710-51-1
Molecular Formula	C46H74N14O13S
Molecular Weight	1031.2 g/mol
Synonyms	Pmel17 (185-193) peptide; Melanocyte protein Pmel 17 fragment 185-193; gp100 (185-193) analog; HMB-45 antigen peptide; SILV (185-193) peptide; PMEL (185-193); Melanoma antigen gp100 peptide variant; (Des-Asp187,Met186)-gp100 (185-193)
EINECS	Contact for details

Quality Control

Every batch of our research peptides undergoes rigorous analytical testing to ensure identity, purity, and consistency. Quality is verified by multiple orthogonal methods including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight confirmation, and endotoxin levels is provided with each shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70%
Water Content (K.F.)	≤ 5.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.