Description

(L)-n-Benzyloxycarbonyl--Oxo-Tryptophaneamide CAS NO 255371-72-3 is a protected derivative of the essential amino acid tryptophan, specifically designed for advanced peptide synthesis and pharmaceutical research. This compound is critical for constructing complex peptide chains where the indole side chain of tryptophan requires protection from undesired reactions during synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel therapeutic peptides and biochemical probes.

Application

• Peptide Synthesis Intermediate: A key building block in solid-phase and solution-phase peptide synthesis (SPPS) for incorporating protected tryptophan residues.
• Pharmaceutical Research & Development: Used in the R&D of peptide-based drugs, hormones, and enzyme inhibitors targeting various disease pathways.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled peptides for biochemical and diagnostic assays.
• Academic & Institutional Research: Employed in university and institutional labs for studying protein-protein interactions, peptide structure-activity relationships (SAR), and medicinal chemistry.
• Process Chemistry & Scale-up: Suitable for process optimization and scaling up the production of peptide active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	(L)-n-Benzyloxycarbonyl--Oxo-Tryptophaneamide
CAS No.	255371-72-3
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	Z-Trp-NH2; Nα-Cbz-Tryptophanamide; N-Carbobenzoxy-L-tryptophan amide; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamide; Cbz-L-Trp-NH2; L-Tryptophanamide, N-[(phenylmethoxy)carbonyl]-; Benzyloxycarbonyl-L-tryptophanamide; Nα-Z-L-Tryptophanamide
EINECS	Contact for details

Quality Control

Our (L)-n-Benzyloxycarbonyl--Oxo-Tryptophaneamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and cGMP applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.