Description

Fmoc-4-Amino-3-Methoxybenzoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the 4-amino-3-methoxybenzoic acid moiety into peptide chains, enabling the creation of complex, non-natural peptides for research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in drug discovery, proteomics, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research & Drug Discovery: Used in the development of novel peptide-based drug candidates, including enzyme inhibitors and receptor agonists/antagonists.
• Proteomics and Biochemical Research: Incorporation into peptide probes and substrates for studying enzyme activity and protein-protein interactions.
• Combinatorial Chemistry Libraries: Serves as a versatile monomer for generating diverse peptide libraries for high-throughput screening.
• Synthesis of Peptide Mimetics: Enables the creation of modified peptides with enhanced stability, bioavailability, or specific biological activity.
• Antibody-Drug Conjugate (ADC) Linker Research: Potential use in the design and synthesis of specialized linker components for targeted drug delivery systems.

Basic Information

Product Name	Fmoc-4-Amino-3-Methoxybenzoic Acid
CAS No.	254737-60-5
Molecular Formula	C23H19NO5
Molecular Weight	389.40 g/mol
Synonyms	Fmoc-4-Amino-3-methoxybenzoic acid; 4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-methoxybenzoic acid; 3-Methoxy-4-[(9-fluorenylmethyloxycarbonyl)amino]benzoic acid; Fmoc-3-Methoxy-4-aminobenzoic Acid; N-Fmoc-4-amino-3-methoxybenzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-4-aminobenzoic acid; Fmoc-AMB-OH
EINECS	Contact for details

Quality Control

Our Fmoc-4-Amino-3-Methoxybenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Assay	95.0% - 102.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.