Description

Benzenamine, 2-Methoxy-5-(Trifluoromethyl)- (Hydrochloride)(1:1) is a specialized aromatic amine hydrochloride salt, a key building block in advanced organic synthesis. This compound is valued for its trifluoromethyl and methoxy substituents, which impart unique electronic and steric properties critical for developing high-performance materials and active pharmaceutical ingredients. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecules with enhanced bioactivity and material characteristics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Acts as a key aromatic amine component in the production of electron-transport materials, hole-blocking layers, and other functional materials for display and lighting technologies.
• Polymer Modification: Employed to introduce functional amine groups into polymer backbones, modifying properties like adhesion, solubility, and thermal stability for high-performance coatings and resins.
• Dye & Pigment Manufacturing: Functions as an intermediate in the synthesis of complex azo dyes and high-value pigments, contributing to color fastness and spectral properties.
• Cross-Coupling Reactions: A valuable substrate in Buchwald-Hartwig amination and other palladium-catalyzed cross-coupling reactions to form C-N bonds.

Basic Information

Product Name	Benzenamine, 2-Methoxy-5-(Trifluoromethyl)- (Hydrochloride)(1:1)
CAS No.	254435-23-9
Molecular Formula	C8H9F3NO • HCl
Molecular Weight	231.62 g/mol (Free base: 191.16 g/mol)
Synonyms	2-Methoxy-5-(trifluoromethyl)aniline hydrochloride; 2-Methoxy-α,α,α-trifluoro-p-toluidine hydrochloride; 5-(Trifluoromethyl)-2-methoxyaniline hydrochloride; 2-Amino-5-(trifluoromethyl)anisole hydrochloride; 2-Methoxy-5-trifluoromethylphenylamine hydrochloride; 2-Methoxy-5-(trifluoromethyl)benzenamine hydrochloride; AN-562/34234066; 254435-23-9
EINECS	Contact for details

Quality Control

Our Benzenamine, 2-Methoxy-5-(Trifluoromethyl)- (Hydrochloride)(1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.