Description

Tat (48 - 57) CAS NO 253141-50-3 is a synthetic peptide fragment derived from the HIV-1 Tat protein, specifically encompassing amino acid residues 48 to 57. This sequence is a critical functional domain, making it an essential research tool for studying viral transactivation, cell-penetrating peptide (CPP) mechanisms, and intracellular drug delivery systems. It is primarily utilized by researchers and developers in pharmaceutical R&D, biotechnology, and academic laboratories focused on virology, neurobiology, and novel therapeutic delivery platforms.

Application

• Biomedical Research: Fundamental studies on HIV-1 Tat protein function, structure-activity relationships, and viral replication mechanisms.
• Cell-Penetrating Peptide (CPP) Studies: Investigation of membrane translocation properties for enhancing the cellular uptake of therapeutic molecules, drugs, and diagnostic agents.
• Drug Delivery System Development: A key component in the design and evaluation of novel conjugates and vectors aimed at targeted intracellular delivery.
• Neuroscience Research: Exploration of neurotoxic and neuroprotective pathways associated with HIV-associated neurocognitive disorders (HAND).
• Immunology & Vaccine Research: Used as an antigenic peptide in epitope mapping and the development of diagnostic assays or vaccine candidates.
• Bioconjugation & Protein Engineering: Serves as a functional tag or module for modifying proteins, nanoparticles, or other biomolecules to confer cell-penetrating abilities.

Basic Information

Product Name	Tat (48 - 57)
CAS No.	253141-50-3
Molecular Formula	C52H78N16O11
Molecular Weight	1087.3 g/mol
Synonyms	TAT (48-57); HIV-1 Tat Protein (48-57); GRKKRRQRRR; Tat Peptide (48-57); Cell-Penetrating Peptide Tat (48-57); HIV-1 Transactivator of Transcription Peptide Fragment; TAT47-57; Arginine-rich Motif Peptide
EINECS	Contact for details

Quality Control

Our Tat (48 - 57) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.