Description

H-L-Lys(Fmoc)-Oh·Hcl is a protected amino acid derivative, specifically the Fmoc-protected form of L-lysine hydrochloride. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research & Development: Used as a key intermediate in the discovery and production of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Labeling: The reactive side-chain amine (protected) and carboxyl group allow for site-specific modifications and the creation of peptide-protein conjugates.
• Combinatorial Chemistry Libraries: Serves as a building block for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme mechanisms, and as a standard in analytical methods.
• Antibody-Drug Conjugate (ADC) Development: Can be incorporated into linker-payload systems for targeted cancer therapies.

Basic Information

Product Name	H-L-Lys(Fmoc)-Oh·Hcl
CAS No.	253138-02-2
Molecular Formula	C₂₁H₂₅ClN₂O₄
Molecular Weight	404.89 g/mol
Synonyms	Fmoc-Lys-OH·HCl; Nα-Fmoc-L-lysine hydrochloride; Nα-(9-Fluorenylmethoxycarbonyl)-L-lysine hydrochloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride; Fmoc-L-Lysine hydrochloride; Fmoc-Lysine-OH·HCl; Nε-Boc-Nα-Fmoc-L-lysine hydrochloride (Note: This is a different, doubly-protected derivative; included for clarity).
EINECS	Contact for details

Quality Control

Our H-L-Lys(Fmoc)-Oh·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR/IR for structural confirmation. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	+14.0° to +18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.