Description

Apelin-36 (Human) is a synthetic 36-amino acid peptide that acts as the endogenous ligand for the APJ receptor, a G-protein-coupled receptor. This compound is crucial for researchers investigating the apelinergic system, which plays significant roles in cardiovascular function, fluid homeostasis, and metabolic regulation. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic development in the life sciences sector. Apelin-36 (Human) CAS NO 252642-12-9 is supplied to meet the stringent requirements of high-purity biochemical applications.

Application

• Biomedical Research: Fundamental studies on the physiological and pathological roles of the apelin/APJ system in cardiovascular diseases, diabetes, and obesity.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) and lead optimization for novel APJ receptor agonists or antagonists.
• Cell Signaling Studies: Investigation of intracellular signaling pathways (e.g., MAPK, PI3K/Akt) activated upon APJ receptor binding in various cell lines.
• In Vitro & Ex Vivo Assays: Functional characterization of receptor activity, including cAMP accumulation, calcium mobilization, and β-arrestin recruitment assays.
• Biomarker & Diagnostic Development: Potential use in developing assays to measure apelin levels in biological fluids for research purposes.
• Academic & Institutional Research: A key reagent for universities and research institutes studying endocrinology, neurobiology, and cardiovascular physiology.

Basic Information

Product Name	Apelin-36 (Human)
CAS No.	252642-12-9
Molecular Formula	C185H294N56O53S
Molecular Weight	4195.8 g/mol
Synonyms	Apelin-36; Human Apelin-36; Pyr-1-Apelin-36; Apelin (65-100) (human); Pyr-apelin-36; L-Pyroglutamyl-apelin-36; APLN (65-100); APJ receptor ligand; UNII-9K9N8B73QI
EINECS	Contact for details

Quality Control

Our Apelin-36 (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity determination and Mass Spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical data. Our quality commitment aligns with standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.