Description

4-(Methylsulphonyl)-3-(Trifluoromethyl)Aniline, 4-Amino-2-(Trifluoromethyl)Phenyl Methyl Sulphone is a high-value, multi-functional aromatic amine building block characterized by its trifluoromethyl and methylsulfonyl substituents. This compound is essential for synthesizing advanced molecules where electronic modulation and metabolic stability are critical. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, including kinase inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the trifluoromethyl group for enhanced bioactivity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and signal transduction pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated aromatic structures.

Basic Information

Product Name	4-(Methylsulphonyl)-3-(Trifluoromethyl)Aniline, 4-Amino-2-(Trifluoromethyl)Phenyl Methyl Sulphone
CAS No.	252561-92-5
Molecular Formula	C8H8F3NO2S
Molecular Weight	239.21 g/mol
Synonyms	4-Amino-2-(trifluoromethyl)phenyl methyl sulfone; 3-(Trifluoromethyl)-4-(methylsulfonyl)aniline; 4-(Methylsulfonyl)-3-(trifluoromethyl)benzenamine; 2-(Trifluoromethyl)-4-aminophenyl methyl sulphone; 4-Methylsulfonyl-3-trifluoromethylaniline; 252561-92-5; Benzenamine, 4-(methylsulfonyl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylsulphonyl)-3-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.