Description

Fmoc-L-Arg(Pbf)-Nh2 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides the critical arginine building block with orthogonal protecting groups, ensuring precise and efficient peptide chain assembly. Pharmaceutical researchers, biotechnology companies, and CROs specializing in peptide-based drug discovery and development need this reagent for creating complex therapeutic peptides, hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated and manual synthesis of peptide sequences containing arginine.
• Pharmaceutical R&D: For the research and development of novel peptide therapeutics, including anticancer agents, antimicrobial peptides, and metabolic disorder treatments.
• Bioconjugation: Used in the preparation of peptide-protein conjugates, peptide-drug conjugates (PDCs), and other bioconjugates for targeted therapies.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening to identify new bioactive peptide leads.
• Academic Research: Employed in university and institutional labs for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• API Intermediate Manufacturing: Serves as a critical raw material in the cGMP production of peptide Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-L-Arg(Pbf)-Nh2
CAS No.	252348-72-4
Molecular Formula	C33H47N5O7S
Molecular Weight	657.83 g/mol
Synonyms	Fmoc-Arg(Pbf)-NH2; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-argininamide; Fmoc-L-arginine(Pbf)-amide; Fmoc-Arg(Pbf)-NH2; Nα-(9-Fluorenylmethoxycarbonyl)-Nω-[2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl]-L-argininamide; Fmoc-Arg(Pbf)-Amide; Fmoc-Arg(Pbf)-CONH2; Fmoc-Arginine(Pbf)-Amide
EINECS	Contact for details

Quality Control

Our Fmoc-L-Arg(Pbf)-Nh2 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical R&D and production. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.