Description

Tertiapin-Q is a high-purity, synthetic peptide toxin known for its potent and selective inhibition of inward-rectifier potassium (Kir) channels. This specificity makes it an invaluable research tool for studying ion channel physiology and pathophysiology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, cardiovascular research, and drug discovery programs. The compound is supplied under stringent quality control to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: Used to study the role of G protein-gated inward-rectifier potassium (GIRK/Kir3.x) channels in neuronal excitability, synaptic transmission, and neurological disorders.
• Cardiovascular Pharmacology: Employed as a selective probe to investigate the function of Kir channels in cardiac myocytes, affecting heart rate and action potential duration.
• Drug Discovery & Screening: Serves as a reference standard and pharmacological tool in high-throughput screening assays to identify novel modulators of Kir channels.
• Ion Channel Characterization: Essential for electrophysiology studies (e.g., patch-clamp) to block specific Kir currents and characterize channel subtypes in recombinant or native cell systems.
• Metabolic Disorder Studies: Applied in research exploring the link between pancreatic β-cell Kir channels (like Kir6.2) and insulin secretion mechanisms.
• Biochemical Assay Development: Used in the development and validation of binding assays and other in vitro test systems targeting Kir channel activity.

Basic Information

Product Name	Tertiapin-Q
CAS No.	252198-49-5
Molecular Formula	C119H194N40O33S4
Molecular Weight	~2740.3 g/mol
Synonyms	Tertiapin Q; TPN-Q; APETx4; Honey bee venom peptide Tertiapin-Q; Inhibitor of GIRK1/4 and ROMK1 channels; Kir3.1/3.4 channel blocker; Kir1.1 channel blocker
EINECS	Contact for details

Quality Control

Every batch of Tertiapin-Q is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity is provided with each shipment to guarantee traceability and performance consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified on COA
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.