Description

Fmoc-β-(2,2-Dimethyl-4H-Benzo[1,3]-Dioxin-6-Yl)-Ala-Oh is a specialized, non-natural amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing unique, conformationally constrained side chains into peptide sequences, enabling the development of novel bioactive molecules with enhanced stability and specificity. It is an essential building block for pharmaceutical R&D teams, academic researchers, and CROs focused on peptide-based drug discovery, proteomics, and the development of diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: For creating peptide therapeutics with modified backbones to improve metabolic stability, bioavailability, and target binding affinity.
• Chemical Biology & Proteomics: Used to synthesize peptide probes, inhibitors, and activity-based probes for studying protein function and interactions.
• Material Science: Incorporation into peptidomimetics and bio-inspired polymers to create novel materials with specific functions.
• Antibody-Drug Conjugate (ADC) Development: Potential use in constructing specialized linker-payload systems.
• Academic Research: A valuable reagent for studying structure-activity relationships (SAR) and peptide folding.

Basic Information

Product Name	Fmoc-β-(2,2-Dimethyl-4H-Benzo[1,3]-Dioxin-6-Yl)-Ala-Oh
CAS No.	252049-13-1
Molecular Formula	C29H27NO6
Molecular Weight	485.53 g/mol
Synonyms	Fmoc-β-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-L-alanine; Fmoc-Tic(2,2-Dimethyl-4H-Benzo[1,3]Dioxin-6-yl)-OH; Fmoc-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-L-alanine; Nα-Fmoc-3-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-L-alanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-β-(2,2-Dimethyl-4H-Benzo[1,3]-Dioxin-6-Yl)-Ala-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure the highest standards of purity and consistency required for sensitive research and development applications. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.