Description

Fmoc-Lys(Nicotinoyl)-Oh CAS NO 252049-11-9 is a specialized, side-chain protected derivative of lysine featuring an Fmoc-protected α-amino group and a nicotinoyl group on the ε-amino side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of lysine residues with orthogonal protection strategies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing complex peptides, peptidomimetics, and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated, stepwise synthesis of complex peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based drugs, including hormones, antibiotics, and targeted therapeutics.
• Bioconjugation and Labeling: The reactive side-chain and orthogonal protecting groups facilitate site-specific modifications for creating peptide-drug conjugates or diagnostic probes.
• Combinatorial Chemistry Libraries: Serves as a building block for generating diverse libraries of peptide compounds for high-throughput screening.
• Academic & Institutional Research: Employed in biochemical and structural biology studies to investigate protein-protein interactions and enzyme mechanisms.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Lys(Nicotinoyl)-Oh
CAS No.	252049-11-9
Molecular Formula	C30H29N3O6
Molecular Weight	527.57 g/mol
Synonyms	Fmoc-Lys(Nic)-OH; Nα-Fmoc-Nε-nicotinoyl-L-lysine; Fmoc-L-lysine(Nε-nicotinoyl); 9-Fluorenylmethyl Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-Nε-(pyridine-3-carbonyl)-L-lysinate; Fmoc-Lys(Nicotinyl)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(nicotinamido)hexanoic acid; Fmoc-Lys(Nicotinic acid amide)-OH; Nα-Fmoc-Nε-(3-pyridylcarbonyl)-L-lysine
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Nicotinoyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis. Specifications are verified by advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.