Description

Fmoc-D-Threoninol CAS NO 252049-02-8 is a high-purity, enantiomerically pure amino alcohol derivative, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating therapeutic peptides, and in advanced materials science for constructing molecular scaffolds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral precursor for the controlled incorporation of D-threoninol residues into peptide chains.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Peptidomimetic Design: Serves as a building block for creating stable, non-natural peptide analogs with enhanced biological activity and metabolic stability.
• Bioconjugation and Linker Chemistry: The amino and hydroxyl functionalities allow for selective modification and attachment to other molecules or surfaces.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of chiral compounds for high-throughput screening in drug discovery.
• Material Science: Used in the synthesis of specialized polymers and dendrimers with precise chiral architectures.

Basic Information

Product Name	Fmoc-D-Threoninol
CAS No.	252049-02-8
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-D-threoninol; (2R,3S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-hydroxybutan-1-ol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-threoninol; D-Threoninol, N-Fmoc-; Fmoc-D-Thr-ol; N-Fmoc-D-threoninol; (2R,3S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1,3-butanediol
EINECS	Contact for details

Quality Control

Our Fmoc-D-Threoninol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.